Research
I study how disease-relevant biology can be understood across scales, from molecular mechanism and cellular regulation to inflammation, immunity, and clinically anchored human evidence. My aim is to connect mechanism, computation, and human disease within a single interpretive framework.
Mechanism and controlled perturbation
A central part of my research has focused on how aberrant Wnt/β-catenin signaling, frequently dysregulated in cancer, extends into cell-cycle control, mitosis, and centrosome biology, thereby promoting chromosomal instability. This work later extended into chromatin regulation and neurodevelopmental disease and it continues to inform my use of controlled experimental systems, including lentiviral approaches to test mechanism in an interpretable way.
Inflammation, immunity, and disease context
I work on disease in immunological context, particularly where epithelial state, inflammatory signaling, adaptive immune responses, and immune repertoires begin to shape pathology. A central interest is how chronic inflammation is initiated and sustained. That includes the search for antigens, exposures and virus-associated immune risk in autoimmune disease, with particular attention to Epstein-Barr virus (EBV) and infectious mononucleosis (IM).
Clinically anchored human evidence
A focus of my work is the use of patient-linked cohorts, epidemiological reasoning, and real-world clinical data to test whether biological signals remain meaningful in human disease. I am particularly interested in approaches that preserve rigor and interpretability while linking mechanistic questions to clinically observed outcomes.
Trajectory and current direction
My research was shaped first by mechanistic discovery in Wnt/β-catenin signaling, cell-cycle regulation, and chromosomal instability, and later extended into chromatin regulation, immune-mediated disease, and clinically grounded human data. Across these settings, the underlying aim remains the same: to connect mechanistic biology to human disease in a coherent way.
Institutional coverage:
IKMB feature on two recent studies in Blood and Cell Metabolism